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产品目录

Thymidylate synthase/TYMS抗体图片
产品货号:
Z28129
中文名称:
Thymidylate synthase/TYMS抗体
英文名称:
Anti-Thymidylate synthase/TYMS Antibody
产品规格:
100μg
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-Thymidylate synthase/TYMS Antibody
指标别名HsT422;Thymidylate synthase;thymidylate synthetase;TMS;TS;TSase;TYMS
克隆性Polyclonal
检验物种human
应用范围WB
基因名称TYMS
抗体来源Sheep
抗体类型IgG
免疫原Anti-THYMIDYLATE SYNTHASE was purified from rabbit serum after repeated immunizations with recombinant human Thymidylate Synthase (36kDa) produced in E.coli.
成分0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide
纯化方式Anti-THYMIDYLATE SYNTHASE IgG fraction is directed against human Thymidylate Synthase and is useful in determining its presence in various assays.Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation,the enzyme is an important target for cancer chemotherapeutic drugs,specifically the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors.In general,this antibody can detect antigen in a variety of human cells and tissues,as well as bacteria,African green monkey,rat and mouse.Somewhat lower dilutions may be required in some non-human cell lines.?Anti-Thymidylate Synthase can detect Thymidylate Synthase by immunochemistry in proliferating cell cultures and tissues but does not stain nonproliferating cells.Normal colon mucosa shows weak staining;however,some colorectal cancer specimens show very strong staining.
浓度1mg/mL by UV absorbance at 280nm
产品形态Lyophilized
保存条件Store vial at 4℃ prior to restoration.For extended storage aliquot contents and freeze at -20℃ or below.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.?Expiration date is one (1) year from date of opening.
背景资料Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor.This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair.The enzyme has been of interest as a target for cancer chemotherapeutic agents.It is considered to be the primary site of action for 5-fluorouracil,5-fluoro-2-prime-deoxyuridine,and some folate analogs.Expression of this gene and that of a naturally occurring antisense transcript rTSalpha vary inversely when cell-growth progresses from late-log to plateau phase.Diseases associated with Thymidylate synthase include Rectal Neoplasm and Dihydropyrimidine Dehydrogenase Deficiency.Anti-Thymidylate synthase is useful for researchers interested in Circadian Rhythm,Metabolism and cell cycle research.
Uniprot IDP04818
推荐稀释比ELISA:1:10,000 - 1:50,000
IHC:User Optimized
IF Microscopy:User Optimized
WB:1:500 - 1:2,000

相关搜索:Thymidylate synthase/TYMS抗体Thymidylate synthase抗体TYMS多抗Anti-Thymidylate synthase/TYMS Antibody
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